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Taken together these data indicate that primary human keratinocytes mount an inflammatory response to imiquimod that is independent of the canonical imiquimod receptor, TLR7.

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Reports of local skin reactions are summarized in FIG.

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It is also believed that the formulations of the present invention, including the formulations identified in this Example 23, have Hydrophilic-lipophilic balance (HLB) values between about 12 and 15, and more preferably between about 12.

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The concern would be that this would reduce the of diagnostic criteria, as individuals with medulloblastoma undergoing radiotherapy without NBCCS are likely to develop more than one BCC.

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In all other ways it is the same medicine with the same active ingredients, identical in use, safety, strength and all other characteristics.

It is used to treat skin harmed by the sun and some skin cancers.

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Because LGAIN has low potential for malignancy, we recommend that patients with LGAIN attend for annual evaluation, including digital anal examination, anal cytology, and high-resolution anoscopy (HRA) for early detection of progression of HGAIN.

It is also used to treat warts on or around the genitals or anus in people 12 years and older as well as to treat superficial basal cell carcinoma in adults with a normal immune system when surgery is not recommended.

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Eighty-seven percent (87%) of the Diclofenac Sodium Gel treated patients (183 patients) and 84% of the vehicle-treated patients (178 patients) experienced one or more adverse events (AEs) during the studies.

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NFκB activation to the same level as wildtype E7 and secreted cytokine levels similar to the control samples.

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Seventy-seven patients discontinued use of medication during the study, and the discontinuation rate was similar for each group".

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In addition, from a healthcare policy perspective, studies have shown that the use of imiquimod is more cost-effective than surgical interventions among patients with superficial BCC.

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They are usually solitary lesions, although multiple lesions have been reported in rare, genetic diseases such as familial multiple lipomatosis and benign symmetric lipomatosis.

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The complementary method of claim 1, wherein the application step comprises: applying the lower dosage strength pharmaceutical formulation to the treatment area at least once per day for up to two weeks.

The treatment area (face) can not have been treated with imiquimod within one year; with dermatologic procedures or surgeries, any AK therapy, or investigational drug or device within 90 days; or with any topical prescription drugs within 30 days.

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In these assays imiquimod but not CL264 was able to induce NFκB-driven luciferase expression () and this was complimented with increases in CCL20 secretion from treated cells ().

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If the secondary efficacy variable of partial clearance is found to be superior to placebo in either of the active treatment groups, then the secondary efficacy variable of percent reduction is tested.

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The tumor is a scaly, indurated, irregular maculopapular lesion which shows an exo- or endophytic growth pattern with a hyperkeratotic or ulcerating surface, sometimes accompanied by seroanguinous exudates (Fig.

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The number of AK lesions to be treated in the treatment area may range from about 5 to about 20 or more.

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Complete regression after treatment (total clearance of the warts).

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T-helper (Th) CD41 cells have been implicated as major immunoregulators in wound healing.

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